#11 South Florida vs. #6 Louisville Picks and Predictions: Round of 64

Nate Hornung

Written by: Nate Hornung

Published: Wed Mar 18, 2026, 4:48 pm ET

Read Time: 5 minutes

Can the Cardinals escape South Florida without Mikel Brown Jr.? South Florida Louisville Picks

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South Florida Bulls logo
Tomorrow1:30 pm ET
Louisville Cardinals logo

South Florida Bulls
Odds

Spread

Total

Moneyline

+4.5

-110

165

-105u

+170

Louisville Cardinals
Odds

Spread

Total

Moneyline

-4.5

-105

164

-110o

-185

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Nate Hornung
Nate Hornung

Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.

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