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San Francisco 49ers vs Philadelphia Eagles Picks

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<p data-start="790" data-end="948">The defending Super Bowl champion Philadelphia Eagles begin their quest for a repeat in the Wild Card round on Sunday, when they host the San Francisco 49ers.</p>
<p data-start="245" data-end="310">Kickoff is set for 4:30 p.m. ET, with FOX carrying the broadcast.</p>
<p data-start="312" data-end="566" data-is-last-node="" data-is-only-node="">There has been significant line movement toward the home favorite &#8211; but is it justified, or is now the time to consider the road underdog? Below, I’ll tell you what to play with my Philadelphia Eagles vs. San Francisco 49ers preview and bets.</p>
<p><em>For additional information on picks, props, moneylines, and more on today’s slate, take a look at our <a href="http://bettingnews.com/nfl/picks/" target="_blank" rel="noopener">NFL Picks Page</a> or our <a href="http://bettingnews.com/nfl/odds/" target="_blank" rel="noopener">NFL Odds Page</a>.</em></p>
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<h2>Philadelphia Eagles vs San Francisco 49ers Preview &amp; Bets</h2>
<div id="attachment_75950" style="width: 1034px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-75950" class="wp-image-75950 size-full" src="https://wp.bettingnews.com/wp-content/uploads/2025/06/jalen-hurts-eagles-super-bowl-59-celebration.jpg" alt="" width="1024" height="577" srcset="https://wp.bettingnews.com/wp-content/uploads/2025/06/jalen-hurts-eagles-super-bowl-59-celebration.jpg 1024w, https://wp.bettingnews.com/wp-content/uploads/2025/06/jalen-hurts-eagles-super-bowl-59-celebration-300x169.jpg 300w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /><p id="caption-attachment-75950" class="wp-caption-text">Can Jalen Hurts and the Eagles defend last year&#8217;s Super Bowl?</p></div>
<h3>Eagles vs 49ers Preview </h3>
<p data-start="161" data-end="471">It seems much of the public is perplexed by this game’s line movement. The Eagles opened as a 3.5-point favorite but have since been bet up as high as -6. Admittedly, that’s an abrupt shift over the course of the week, but even so, I’m not surprised that Philadelphia has drawn this level of betting attention.</p>
<p data-start="473" data-end="631">There is a massive gap between these teams on the defensive side of the ball, and that disparity should ultimately prove to be the difference in this matchup.</p>
<p data-start="633" data-end="808">The Eagles finished the regular season ranking top-10 in both defensive EPA per play and success rate. Meanwhile, the 49ers rank 30th in success rate and 24th in EPA per play.</p>
<p data-start="810" data-end="1234">San Francisco has become a different team over the second half of the season, largely due to the return of their starting quarterback, Brock Purdy. Since his return in Week 11, Purdy ranks second in CPOE, third in success rate and fourth in EPA per play. He led the 49ers to a six-game winning streak before they dropped their regular-season finale, losing 13-3 to the Seattle Seahawks and missing out on a first-round bye.</p>
<p data-start="1236" data-end="1661">Before that loss, Purdy had been electric. The issue is that his defense has been the complete opposite. Robert Saleh’s unit has shown slight improvement since Purdy returned, ranking 24th in success rate and 19th in EPA per play over that span, but those numbers are still concerning &#8211; especially when you consider that the Eagles’ defense improved to sixth in success rate and fifth in EPA per play during the same stretch.</p>
<p data-start="1663" data-end="2053">One glaring red flag for this 49ers defense is their run defense. Since Week 11, they rank 31st in rush success rate allowed. Philadelphia’s offensive identity is built around the run. While they struggled to find consistency on the ground early in the season, Saquon Barkley has gained momentum down the stretch and should be well-positioned to exploit this vulnerable San Francisco front.</p>
<p data-start="2055" data-end="2351">Additionally, Jalen Hurts’ dual-threat ability presents another challenge entirely, and he’s done a much better job protecting the football of late. Since his four-interception primetime performance against the Chargers, Hurts owns a 6–0 touchdown-to-interception ratio over his past three games.</p>
<p data-start="2353" data-end="2566">The 49ers finished the season with a -6 turnover differential. Creating turnovers is imperative in the postseason, especially against a team capable of wearing down your defense and controlling time of possession.</p>
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<h3 data-start="2353" data-end="2566">Eagles vs 49ers Bets</h3>
<p><strong>Best Bet: Brock Purdy Over 16.5 Rushing Yards (-110)</strong></p>
<p>This was a tough draw for the 49ers regardless, but when you factor in a cross-country trip into a hostile Philadelphia environment with double-digit winds and cold temperatures, the circumstances become even more difficult.</p>
<p>Earlier this week, when the Eagles were laying -3.5, I held out in hopes that the number might briefly dip to -3. Obviously, that never happened, and I’m not interested in jumping on the spread now that it’s moved several points against me. I do expect Philadelphia to win this game. I believe their defense will generate multiple stops, while the 49ers will have constant issues containing Barkley, Hurts, and the rest of this Eagles offense.</p>
<p data-start="832" data-end="951"><a href="https://www.bettingnews.com/articles/nfl/nfl-playoff-preview-super-bowl-odds-and-predictions/" target="_blank" rel="noopener"><strong>I did take a flyer on the Eagles at +475 to win the NFC Championship,</strong></a> which I still believe is a bet worth considering.</p>
<p data-start="953" data-end="1078">As for an official play in this game, I’m turning to the prop market. My wager is Brock Purdy over 16.5 rushing yards (-110).</p>
<p data-start="1080" data-end="1375">As strong as Vic Fangio’s defense has been, it has shown vulnerability against mobile quarterbacks. Philadelphia allows the second-most rushing yards to opposing QBs this season, allowing an average of 23.5 rushing yards per game &#8211; a number I expect Purdy to push past.</p>
<p data-start="1377" data-end="1672">Purdy isn’t known as a true running quarterback, but he’s quietly been changing that narrative. He’s averaging 16.3 rushing yards per game this season, but that figure has jumped to 26 yards per game over his last four contests. He’s gone over 16.5 rushing yards in three of those four games as well.</p>
<p data-start="1674" data-end="1985" data-is-last-node="" data-is-only-node="">Given how dominant this Eagles secondary is, combined with the expected wind, throwing the ball efficiently could be a challenge. If and when San Francisco falls behind, Purdy will need to find alternative ways to move the chains, and that should create plenty of opportunities for him to do so with his legs.</p>
<p data-start="1674" data-end="1985" data-is-last-node="" data-is-only-node=""><a href="https://affiliates.bettingnews.com/register/luckyrebel-articles/" target="_blank" rel="noopener"><strong>Best Bet: Brock Purdy Over 16.5 Rushing Yards (-110 at Lucky Rebel)</strong></a></p>
<p data-start="1674" data-end="1985" data-is-last-node="" data-is-only-node=""><em>NFL Record: 102-85-1 (+6.81 units)</em></p>
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Get ready for this NFL opening round playoff matchup, with our expert's Philadelphia Eagles vs San Francisco 49ers preview & bets

Philadelphia Eagles vs San Francisco 49ers Preview & Bets (1/10)

Danny Burke