Oakland A’s vs Seattle Mariners Betting Preview (July 22): Flexen Seeks 10th Win as Big AL West Series Starts in Seattle

The AL West is very interesting this season. The Houston Astros and Oakland A’s look like definite playoff contenders and are the MLB betting favorites at the top of the division. But the Seattle Mariners have been a major surprise, and the Los Angeles Angels have managed to hang around while waiting on Mike Trout to return.

Things will get even more intriguing if the A’s struggle in their four-game series in Seattle. They start the series just 3.5 games up on the M’s, and the easy math says a sweep would have them swap their places.

If that were to happen, it would be interesting to see what each team might do next. Might Seattle forget about punting this season and try and reinforce for a playoff run? Would Oakland try and regroup, maybe sell off a pitcher or two? These games just before the trade deadline just have so much more at stake.

These teams have only played each other 6 times this season, splitting their meetings 3-3. From here on out, they are going to be seeing each other a lot. This just kicks that off.

MLB Betting Matchup: Oakland A’s (55-42) vs Seattle Mariners (51-45), Root NW, 10:10 PM ET

Probable Pitchers

• Oakland A’s: Sean Manaea (6-6, 3.28 ERA)
• Seattle Mariners: Chris Flexen (9-3, 3.35 ERA)

A’s vs Mariners MLB Betting Odds

• Moneyline: Oakland -149, Seattle +126
• Total: OVER 7.5 (-113), UNDER 7.5 (-107)
• Run Line: Oakland -1.5 (+118), Seattle +1.5 (-142)

Odds are via BetOnline Sportsbook as of Thursday, July 22 at 9:16 am ET. For MLB betting odds for today’s other matchups, check out our MLB odds.

A’s vs Mariners MLB Betting Consensus

• Moneyline: Oakland 40%, Seattle 60%
• Total: Over 20%, Under 80%
• Run Line: Oakland 20%, Seattle 80%

Oakland A’s vs. Seattle Mariners July 22 MLB Betting Matchup: Picks, Odds, Stats and More

Oakland A’s vs Seattle Mariners MLB Betting Outlook

Are the A’s a Contender or Pretender?

That is a question I have been trying to answer all season. I like their pitching, but now of their arms really dominate. They just seem to have five starters who are good enough to be in any team’s rotation. Their lineup is solid, but until 3B Matt Chapman starts hitting, they are definitely not an upper-tier offensive club. And even if/when he does, they do not have bats like the Astros, Red Sox, or Blue Jays

At this stage of the season, I thought we would be sure that Oakland was going to the playoffs. Now I am not so sure. They do start the series with a little momentum, however. They just put the Angels in their place, outscoring them 10-1 over the last two games.

Mariners in a Tricky Spot as August Approaches

The Mariners were supposed to win with the likes of Kyle Lewis and Dylan Moore…in 2025. Instead, their success to date has made them a viable playoff contender, right now. The smart course of action seems to be to trade off the veterans and continue to build, but GMs and teams do not always do the “smart thing”. The key for Seattle has been outfielder Mitch Haniger. He is having a great season.

Seattle has had lots of success winning close games so far this season. They are 20-8 in one-run games. They are actually -52 runs on the season though, worse than the Angels who are under .500 and below them in the standings. That is why this club is hard to believe in despite their record. They have been profitable from an MLB betting standpoint but picking the right spots is tough.

Sean Manaea Home vs Away

• Home: 4-2, 3.34 ERA, 64.2 IP, 65 Ks, 12 BBs
• Away: 2-4, 3.20 ERA, 45 IP, 50 Ks, 13 BBs

Chris Flexen Home vs Away

• Home: 6-2, 1.76 ERA, 61.1 IP, 43 Ks, 10 BBs
• Away: 3-1, 5.92 ERA, 38 IP, 22 Ks, 10 BBs

Flexen has never had this kind of success in the Majors or pitched this much in the big leagues. That might mean a big fade is coming, but those home splits definitely catch your eye. I have been a big fan of Manaea for a while now. His record might just be 6-6, but the A’s are 12-7 in his starts. He has been very consistent this season, even though he got off to a slow start.

Oakland A’s vs Seattle Mariners July 22 Best Bet

Seattle Mariners ML

It is hard not to like the Mariners at home with Flexen on the hill. The Mariners have won five of his last six starts, and even though a fade is likely over the rest of the summer, he should still be rejuvenated by the All-Star break for now. This one might be low-scoring as I think Manaea will pitch well too. The under might definitely be in play with a couple of lineups that can be easy to navigate.

July 21 Betting Matchups

MLB Betting Matchup: Texas Rangers vs Detroit Tigers, MLB Network, 1:10 PM ET

Probable Pitchers

• Texas Rangers: Mike Foltynewicz (2-9, 5.91 ERA)
• Detroit Tigers: Tyler Alexander (1-1, 4.40 ERA)

Texas Rangers vs Detroit Tigers July 22 Betting Matchup: Picks, Odds, Stats and More

MLB Betting Matchup: Atlanta Braves vs Philadelphia Phillies, NBS Sports Philadelphia, 7:05 PM

Probable Pitchers

• Atlanta Braves: Charlie Morton (8-3, 3.69 ERA)
• Philadephia Phillies: Matt Moore (0-1, 5.25 ERA

Atlanta Braves vs Philadelphia Phillies July 22 Betting Matchup: Picks, Odds, Stats and More

MLB Betting Matchup: Tampa Bay Rays vs Cleveland Indians, Bally Sports Great Lakes 7:10 PM ET

Probable Pitchers

• Tampa Bay Rays: Luis Patina
• Cleveland Indians: Cal Quantrill

Tampa Bay Rays vs Cleveland Indians July 22 Betting Matchup: Picks, Odds, Stats and More

MLB Betting Matchup: San Diego Padres vs Miami Marlins, Bally Sports Florida, 7:10 PM ET

Probable Pitchers

• San Diego Padres: Blake Snell (3-3, 5.21 ERA)
• Miami Marlins: TBD

San Diego Padres vs Miami Marlins July 22 Betting Matchup: Picks, Odds, Stats, and More

MLB Betting Matchup: New York Yankees vs Boston Red Sox, MLB Network 7:10 PM ET

Probable Pitchers

• New York Yankees: Jordan Montgomery (3-5, 4.18 ERA)
• Boston Red Sox: Tanner Houck (0-2, 3.38 ERA)

New York Yankees vs Boston Red Sox July 22 Betting Matchup: Picks, Odds, Stats and More

MLB Betting Matchup: Chicago Cubs vs St. Louis Cardinals, MLB Network, 7:15 PM ET

Probable Pitchers

• Chicago Cubs: Adbert Alzolay (4-9, 4.59 ERA)
• St. Louis Cardinals: Kwang Hyun Kim (5-5, 2.78 ERA)

Chicago Cubs vs St. Louis Cardinals July 22 Betting Matchup: Picks, Odds, Stats and More

MLB Betting Matchup: Los Angeles Angels vs Minnesota Twins, Bally Sports North, 8:10 PM ET

Probable Pitchers

• Los Angeles Angels: Andre Heaney (5-7, 5.56 ERA)
• Minnesota Twins: Kenta Maeda (4-3, 4.71 ERA)

Los Angeles Angels vs Minnesota Twins July 22 Betting Matchup: Picks, Odds, Stats and More

MLB Betting Matchup: San Francisco Giants vs Los Angeles Dodgers, Sportsnet LA, 10:10 PM ET

Probable Pitchers

• San Francisco Giants: Anthony DeScalafani (10-4, 2.78 ERA)
• Los Angeles Dodgers: Walker Buehler (10-1, 2.37 ERA)

San Francisco Giants vs Los Angeles Dodgers July 22 Betting Matchup: Picks, Odds, Stats and More