Rams vs Colts Week 4 Prediction, Odds & Picks: Can Indy Stand Tall at Home?

Betting News' NFL Week 4 coverage continues with another Sunday afternoon matchup that pits the LA Rams one-on-one with the Indianapolis Colts at Lucas Oil Stadium.

For the second straight day, the Colts listed QB Anthony Richardson as a full participant in practice, putting him on track to play Sunday vs. the Rams.

— Adam Schefter (@AdamSchefter) September 28, 2023

The Rams' road trip continues after falling 19-16 to the Cincinnati Bengals in Week 4. Meanwhile, the Colts shocked a lot of people last week as kicker Matt Gay kicked four field goals over 50 yards en route to a 22-19 overtime win over the Baltimore Ravens.

Can LA avoid a third consecutive loss? Or will the Colts solidify their spot atop the AFC South with another victory?

This article has everything you need before Sunday's Rams vs. Colts showdown, including the latest NFL odds, a prediction, and the best bets.

Rams vs Colts — NFL Week 4

LAR vs IND Game Information

• Matchup: LA Rams (1-2, 1-1 Away) vs. Indianapolis Colts (2-1, 0-1 Home)
• Venue & Location: Lucas Oil Stadium (Indianapolis, IN)
• Date: Sunday, Oct. 1, 2023
• Game Time: 1 p.m. Eastern Time
• Rams vs. Colts Week 4 TV Channel: FOX

Rams vs Colts Odds

NFL game odds courtesy of SportsBetting as of Saturday, Sept. 30 at 9:15 p.m. ET. Odds from other sportsbooks may also be mentioned in this article.

Spread

• LA Rams PK (-110)
• Indianapolis Colts PK (-110)

Over/Under

• Over 45 Points (-110)
• Under 45 Points (-110)

Moneyline

• LA Rams TBD
• Indianapolis Colts TBD

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Now, back to some football…

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Rams vs Colts Betting Trends

• The Rams are 1-8 straight up in their last nine road games.
• Indianapolis is 0-6 straight up in its last six home games.
• The Rams are 6-3 ATS in their last nine games against Indianapolis.
• Indianapolis is 4-1 ATS in its last five games against the NFC West.
• The total has hit the Under in eight of the Rams' last 10 games against the AFC.
• The total has hit the Over in each of Indianapolis' last six games vs. the Rams.

Rams vs Colts Week 4 Preview

The Colts will receive a huge boost this weekend with rookie QB Anthony Richardson likely suiting up to face the Rams. The 21-year-old has been sidelined with a concussion suffered in Week 2, but his full participation in practice this week is a great sign for his Week 5 status.

It won't be an easy test, though. The Rams are allowing the seventh-fewest passing yards and have surrendered just one passing touchdown so far. At the same time, they've allowed a rushing TD to quarterbacks, opening the door for Richardson to use his feet.

Speaking of quarterbacks, LA gunslinger Matthew Stafford could find a lot of success this Sunday. Indianapolis' secondary just isn't good, allowing a 69.1% completion percentage (7th-highest) and 250.7 passing yards per game (10th-most).

In other words, the Colts' front seven must pressure Stafford all day long. Indianapolis currently sits 10th when it comes to QB hurries (13) while being tied for the third-most sacks (12) through three games, so the potential is there.

If the Rams want to win this week, they need a stronger start than the one they had against the Bengals. Los Angeles was held to three field goals in the first three quarters of last week's matchup.

It also didn't help that six of the Rams' nine drives during that span ended in punts or interceptions.

The good news for the visitors is that the Colts aren't the greatest team at stopping drives. They're average when it comes to third-down defense (38.3%, No. 17) and allow opponents to score touchdowns on 66.7% of red-zone trips (T-No. 23).

For reference, the Rams sit at No. 2 and T-No. 20 when it comes to third-down and red-zone defense, respectively.

Rams vs Colts Prediction — Week 4

In a matchup that could go either way, I'm taking the Colts to win. The Rams are solid, but there are concerns following back-to-back losses while the Colts have momentum stemming from a win over a strong Ravens squad.

With Richardson looking like he belongs in the NFL, I expect Indianapolis to squeeze out the win at home.

Prediction: Colts 21, Rams 17 — Colts PK (-110 on SportsBetting)

Rams vs Colts Player Prop — Week 4

For those craving a Rams vs. Colts player prop, let's go with Puka Nacua scoring an anytime touchdown.

Although he's yet to find paydirt in the NFL, Nacua has looked tremendous thus far, turning 30 catches in 338 receiving yards. With Stafford targeting him 14 times per game, the 22-year-old WR will have plenty of chances to score against a Colts defense that has given up four TDs to the position already.

Best Player Prop: Puka Nacua Anytime Touchdown (+140 on SportsBetting)

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LA vs Indianapolis Week 4 FAQ

When is Rams vs Colts?

• The Rams and Colts will collide on Sunday, Oct. 1, 2023.

Where is Rams vs Colts?

• The Rams and Colts will play each other at Lucas Oil Stadium in Indianapolis, Indiana.

What time does Rams vs Colts start?

• Kickoff for the upcoming LAR vs. IND matchup is slated for 1 p.m. ET.

How can I watch Rams vs Colts?

• LA and Indy fans can tune in to FOX for Sunday's matchup.

How can I bet on Rams vs Colts?

All of the top online sports betting sites will have NFL odds, but here are some of the sites we recommend most for football enthusiasts.