Milwaukee Brewers vs. St. Louis Cardinals Picks and Predictions: May 4, 2026
Written by: Nate Hornung
Published: Mon May 04, 2026, 3:13 pm ET
Read Time: 4 minutes
mlb
A classic NL Central rivalry is upon us as the Milwaukee Brewers head to Missouri for the first of three games against the St. Louis Cardinals this week. These two will see each other plenty this season, meeting up in Wisconsin before the end of the month, and both begin this series following a loss. Milwaukee had won three straight before losing to the Nationals yesterday, and the Cardinals were looking to sweep the Dodgers before losing at home last night. Who will turn things around and begin this divisional series with a win? Find out with our MLB picks below.
It's been a great start to the year, let's keep it up all summer long!
- MLB YTD
- 18-11 (62.1%)
- +7.33u
Check out the best odds on the market at our top online sportsbooks.
Milwaukee Brewers vs. St. Louis Cardinals MLB Betting Insights
This is the Way pic.twitter.com/n061Gyfqru
— St. Louis Cardinals (@Cardinals) May 4, 2026
The Cardinals are two games back in the NL Central while the Brewers are down 3.5. It's a very tight race in this division, but it is also still very early on in the season. St. Louis is actually in second place of the division with a 20-14 record, despite their run differential being 0. They are actually fourth in the division in run differential, and ironically enough, the Brewers lead the division in that category. So far this year, they've scored 45 more runs than they have allowed.
Milwaukee seems to be blowing teams out in wins, and barely going down in their losses. Will that trend continue tonight against St. Louis on the road? Take a look at the betting odds and pitching information below, and then check out our picks and predictions for this game.
Matchup Information – Brewers vs. Cardinals – May 4
- Venue & Location: Busch Stadium (St. Louis, MO)
- Date: Monday, May 4, 2026
- First Pitch: 7:45 p.m. Eastern
- Broadcast: FS1
Brewers vs. Cardinals Pitching Matchup
- Milwaukee Brewers: RHP Chad Patrick (2-1, 2.57 ERA, 1.25 WHIP)
- St. Louis Cardinals: RHP Kyle Leahy (3-3, 5.52 ERA, 1.67 WHIP)
Brewers vs. Cardinals Betting Odds
Odds are courtesy of our friends at Lucky Rebel Sportsbook, as of May 4, 2026, at 2:34 p.m. eastern. Sign up today and get a $1,250 deposit bonus as well as 50 slot spins immediately in your account and start betting at the sportsbook with the most competitive odds in the industry, and a wide variety of unique markets not offered anywhere else.
Run Line
- Brewers -1.5 (+145)
- Cardinals +1.5 (-177)
Moneyline
- Brewers -115
- Cardinals -106
Total
- Over 8.5 (-122)
- Under 8.5 (+100)
Milwaukee Brewers vs. St. Louis Cardinals MLB Picks
William Contreras leads the Brewers in batting average (.298) and RBIs (23) so far this MLB season
Brewers vs. Cardinals Prediction: Brewers Win and Cover, Over 8.5
Best Bet: Brewers TT Over 4.5 (-105) Lucky Rebel Sportsbook
Although the Cardinals were on a bit of a hot streak, I see the Brewers getting the best of them in this one. Their .239 team batting average actually improves tremendously to .250 against right handed pitchers, and Kyle Leahy has had a rough year.
He's allowed two earned runs in all six starts, giving up at least three in four of six outings as well. In his last two starts, through just 10.1 innings, Leahy has given up 17 hits, two home runs, three walks, and seven earn runs against the Pirates and Marlins. His splits actually get worse at home, where is ERA balloons up to 6.00 and his WHIP to 1.78.
Over the last week, Milwaukee ranks fifth in the MLB in team batting average, hitting an incredible .269, and ranking third in OBP. Leahy lets plenty of guys on base, so I see the Brewers having no issues getting them around to score some runs.
Still Want More MLB Content?
Here at Betting News, we offer Free Expert Picks for every major sports league. We also host daily streams on our Twitch Channel with our best bets, as well as sweat out games on Playback! Be sure to tune into everything we have going on at our Youtube, TikTok, and X pages as well. Be sure to follow my personal X account as well, @Shaggy_Bets for my full daily card.
More MLB News
MLB Betting News
(6/20) MLB | The Daily Dinger Report — Saturday Night Dingers
MLB Betting News
Toronto Blue Jays vs Chicago Cubs Picks & Props June 20th, 2026
MLB Betting News
(6/19) MLB | The Daily Dinger Report — Friday Dingers
Get FREE Picks and Props Weekly
Sign up for
THE WEEKENDER NEWSLETTER
Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.
This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Betting News makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.