Florida State vs Clemson Prediction, Odds & Picks – NCAAF Week 4: Seminoles Finally Overcome Tigers

The 2023 NCAAF Week 4 schedule features a handful of ACC showdowns, including one on Saturday between the No. 4 Florida State Seminoles and Clemson Tigers.

The CLIMB continues with another conference matchup on the road

🗓️: Saturday
⌚️: Noon ET
📍: Clemson, SC
🏟️: Memorial
📺: ABC
📻: https://t.co/z9h0OLWuNS#NoleFamily | #KeepCLIMBing pic.twitter.com/wipl4PhXoS

— FSU Football (@FSUFootball) September 21, 2023

Florida State remained undefeated through its first conference matchup of the season, scoring a 31-29 win over Boston College last week. On the flip side, Clemson is gunning for its third straight win following a decisive 48-14 victory against Florida Atlantic.

Can the Seminoles continue to cement themselves as a top-25 program? Or will Clemson prove to be too much to handle at home?

This Florida State vs. Clemson betting preview attempts to answer those questions and more. So, strap in and enjoy the ride as we look at the latest NCAAF game odds, as well as a prediction and the best bets.

Florida State vs Clemson Week 4 (Sept. 23)

FSU vs CLEM Game Information

• Matchup: No. 4 Florida State Seminoles (3-0, 1-0 ACC) vs. Clemson Tigers (2-1, 0-1 ACC)
• Venue & Location: Memorial Stadium (Clemson, SC)
• Date: Saturday, Sept. 23, 2023
• Game Time: 12 p.m. Eastern Time
• FSU vs. Clemson TV Channel: ABC

Florida State vs Clemson Odds

NCAAF game odds courtesy of SportsBetting as of Friday, Sept. 22 at 9:43 a.m. ET from. Odds from other sportsbooks may also be mentioned in this article.

Spread

• Florida State Seminoles -1.5 (-110)
• Clemson Tigers +1.5 (-110)

Over/Under

• Over 55.5 Points (-105)
• Under 55.5 Points (-115)

Moneyline

• Florida State Seminoles -120
• Clemson Tigers +100

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Now, back to Saturday's showdown.

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Florida State vs Clemson Betting Trends

• Florida State is 9-0 straight up in its last nine games.
• Clemson is 19-1 straight up in its last 20 home games.
• Florida State is 0-5 ATS in its last five games against Clemson.
• Clemson is 2-12 ATS in its last 14 games played in September.
• The total has hit the Over in each of Florida State's last six games.
• The total has hit the Over in five of Clemson's last six games against Florida State.

Florida State vs Clemson Week 4 Game Preview

While some rivalries go back and forth, one team has dominated this ACC feud for nearly a decade.

Clemson has won seven consecutive games against Florida State, having not lost to the Seminoles since September 2014. The Tigers won most of those encounters by a decent margin, boasting a plus-18.0 average scoring margin along the way.

With that being said, don't expect that dominance to continue. FSU heads into Saturday's matchup having won nine games in a row dating back to the 2022 campaign. Furthermore, the program has won four of its last five ACC showdowns.

Meanwhile, Clemson is already 0-1 against the conference this season, having lost 28-7 to Duke in Week 1. While the Tigers have won back-to-back games since that defeat, Florida Atlantic and Charleston Souther are hardly on FSU's level.

And with all due respect to Duke, Florida State's offense is much more dangerous. The Seminoles rank among the best in the nation when it comes to several offensive categories, including points per game (47.3, No. 3), yards per play (7.2, T-No. 15), and average scoring margin (plus-25.3, No. 12).

That isn't to say that I see FSU dropping 40-plus points tonight. However, I don't see how Clemson can keep up with the visitor's offense considering how the Tigers could only muster up one touchdown against the Blue Devils.

Trusting Clemson isn't any easier when it has covered the spread just twice in its last 14 games played in September. With FSU being 6-1 ATS in its last seven road games, this contest might not be as close as oddsmakers anticipate.

Florida State vs Clemson Prediction Week 4

After years of dominance, it's time for Clemson's winning streak to come to an end. Florida State is one of the best teams in the country and its elite offense gives it an edge against the Tigers, who haven't been tested all that much since Week 1.

Prediction: Florida State 30, Clemson 24 — Florida State -1.5 (-110 on SportsBetting)

Florida State vs Clemson Best Bet

Backing the Over on the 55.5-point total is the best Florida State vs. Clemson bet this time around.

For starters, the Over is 6-0 in FSU's last six games, as well as 4-1 in Clemson's five previous Week 4 matchups. The Seminoles and Tigers have also surpassed their projected total five times in their last six meetings, averaging a combined 59.3 PPG.

With Florida averaging 47.3 PPG and Clemson boasting a 40.3 PPG clip this season, chances are we're in for a shootout come Saturday.

Bet: Over 55.5 Total Points (-105 on Bovada)

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More Betting Content

How can I bet on Florida State vs Clemson?

All of the top online sports betting sites will have NCAAF odds, but here are some of the sites we recommend most for college football enthusiasts.

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• NCAAF Week 4 Must Bet Player Props