Tigres UANL vs. Nashville SC Picks and Predictions: May 5, 2026

Nate Hornung

Written by: Nate Hornung

Last Update: Tue May 05, 2026, 5:53 pm ET

Read Time: 5 minutes

Warren Madrigal has two goals and assists in 10 matches for Nashville this season - MLS Picks

soccer

The Concacaf Champions Cup Semifinals have reached their second legs which begin tonight in Mexico. Tigres UANL of Liga MX faces Nashville SC as the visitors look to dig themselves out of an aggregate deficit. Not only is Tigres leading 1-0, but they also lead 1-0 on away goals, which is the opening tiebreaker between these clubs. Therefore, we are going to see a 90 minute match regardless of the result, unless Nashville wins exactly 1-0. Let's check out our soccer expert's picks in this match.

Check out the best odds on the market at our top online sportsbooks, and be sure to check out tons of picks in different soccer leagues across the world.

Tigres UANL vs. Nashville SC Concacaf Champions Cup Betting Insights

Sam Surridge has been dealing with an injury for Nashville, holding him out of key matches - Nashville SC Tigres UANL Picks

Sam Surridge has been dealing with an injury for Nashville, holding him out of key matches

As I stated above, Tigres lead 1-0 on aggregate. They took down Nashville SC at GEODIS Park last week, and now are back home with a much easier road to the Concacaf Champions Cup Final. While Nashville controlled the ball, maintaining 57% of possession and winning the corner kick battle 7-4, they were unable to defeat Tigres UANL.

The visitors went into Nashville and outshot their hosts 2-7 on frame and 9-13 overall en route to a one goal victory. Now, away goals is the opening tiebreaker. Therefore, Nashville needs to win this match in order to force extra time. If they win 1-0 exactly, then we will see standard extra time followed by a penalty kick shootout if necessary. If Nashville is able to score two goals and win, they would tie things up on aggregate score, and move on based on having more away goals.

Matchup Information – Tigres UANL vs. Nashville SC – May 5

  • Venue & Location: Estadio Universitario (San Nicolás de los Garza, Mexico)
  • Date: Tuesday, May 5, 2026
  • Kick Off: 9:30 p.m. Eastern
  • Broadcast: FS1

Tigres UANL vs. Nashville SC Betting Odds

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Moneyline

  • Tigres UANL -139
  • Draw +255
  • Nashville SC +350

Spread

  • Tigres UANL -1 (+129)
  • Nashville SC +1 (-176)

Total

  • Over 2.5 (-112)
  • Under 2.5 (-120)

Tigres UANL vs. Nashville SC Concacaf Champions Cup Picks

Angel Correa and Tigres UANL defend their one goal aggregate lead over Nashville tonight at home - Nashville SC Tigres UANL Picks

Angel Correa and Tigres UANL defend their one goal aggregate lead over Nashville tonight at home

Best Bet: Tigres UANL ML/Under 4.5 (+105) Lucky Rebel Sportsbook

Feel free to take this down to just 3.5 total goals for +140 if you would rather. I'll admit, 3-1 isn't very likely when looking at the odds in this match, but it's nice to have an extra cushion and still get some plus money. Overall, I think Nashville has given up on this competition. At this point, they have much more to play for in their domestic league, plus they are dealing with several injuries.

If I'm the team from Music City, I care a whole lot more about the long term success of the club this season in the MLS than I do about winning this match and moving on in this competition. Nashville has set themselves up for success going forward in their domestic league, it would suck to piss it all away chasing this trophy.

Look for the visitors to show some pride, but ultimately, they should be more worried about facing D.C. United at home in the MLS this weekend. If they move on, great, but Nashville's focus should be on their play in the MLS, even if that means sacrificing today's result.

Prediction: Tigres UANL Wins 2-1 (+750)

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Nate Hornung
Nate Hornung

Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.

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