Early Bets for Week 6: NCAA Football Expert Picks (10/10)
Written by: PJ Glasser
Published: Tue Oct 06, 2026, 8:56 am ET
Read Time: 5 minutes
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We have made it to Week 6 of College Football. I have my eye already on 3 games that I would bet. One in the SEC and two in the BIG 10. Let's dive into them.
Check out the best odds on the market and tons of picks for the NCAA Football Season.
Texas A&M vs Missouri NCAA Football Picks
Marcel Reed and the Aggies look for a ranked win on the road
Best Bet: Texas A&M +4 (-115) LuckyRebel
It's funny how this week Missouri is in the same spot that went up against last week. On Saturday, Mizzou faced the Florida Gators who had scored 200+ points in their first 4 games. Everyone was loving Florida and Mizzou showed up and smoked them. Now that the Tigers have that big win their stock is sky high. They're facing an A&M team that was top 10 in the preseason, already has two losses and is currently unranked.
I think this line being at Missouri -4 tells you A&M is the side in this one. I was down on A&M coming into the year. Aggies under 8.5 wins was my favorite win total of the offseason. No surprise to me they maybe aren't as good as people thought coming into the season. With that being said I think this is a great spot for them. After two bad losses to Kentucky and LSU the Aggies needed a get-right-game and they got it vs Arkansas. I expect this game to be low scoring and close and I think anything over a field goal is worth a bet on Texas A&M.
USC vs Penn State NCAA Football Picks
Rocco Becht is still looking for his first Big Ten win as Penn State's starter
Best Bet: Penn State ML (-115) LuckyRebel
This game is easily my favorite bet of the week. I love Penn State. Love them. I ALWAYS will bet the games where USC has to travel multiple time zones. Since Lincoln Riley has become head coach at USC the Trojans are awful when they play a game in the central or eastern time zone. 3-7 straight up and 1-9 ATS. They are always an auto fade in these kind of games.
On top of that what a spot this is for Penn State. Off two bad losses to Wisconsin and Northwestern and this is their famous "whiteout game". Arguably the best atmosphere we see in college football every year. We're getting Penn State on the moneyline at -115. I absolutely love it. Lincoln Riley never ever covers these kinds of games and I'll gladly keep betting against him until he proves me wrong.
Minnesota vs Purdue NCAA Football Picks
Can the Gophers stay unbeaten in BIG 10 play?
Best Bet: Purdue +2.5 (-112) LuckyRebel
Minnesota is off to a 2-0 start in BIG 10 play with two really solid wins against Washington and Michigan as underdogs. Now they are a slight road favorite at Purdue with games vs Iowa, Indiana, and UCLA on deck. Definitely feels like the game to fade the Gophers.
Purdue has been REALLY bad the last few years, but this season they're showing progress. After the last two seasons of not winning a conference game they got their first win against Illinois on Saturday. They also put up 38 points on a good UCLA team and took Wake Forest to double overtime. Purdue I think is a better team then people realize and now that they have that conference win off their chest it feels like a weight has been lifted.
Two huge wins in a row for PJ Fleck and Minnesota, can they take care of business against Purdue? I don't think they do.
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