Will Indiana bounce back vs Michigan? NCAA Football Expert Picks (10/24)
Written by: PJ Glasser
Last Update: Wed Oct 21, 2026, 10:45 am ET
Read Time: 5 minutes
ncaaf
Spread
Total
Moneyline
-7.0
-110
41.5
-110u
-280
Spread
Total
Moneyline
+7.0
-105
41.5
-110o
+244
A big one in the Big House on Saturday! Michigan is looking for another upset at home, while Indiana is looking to bounce back after the loss at home to Ohio State.
Check out the best odds on the market and tons of picks for the NCAA Football Season.
NCAA Football Expert Insights: Indiana vs Michigan
We finally got to see Indiana play a highly ranked team on Saturday and it was a close game as expected. The Hoosiers lost 19-15 to Ohio State and had a chance to win the game in the final minute. If Nick Marsh catches the pass from Josh Hoover in bounds then Indiana is probably the #1 team in the country right now. Instead, his foot is out, Indiana is ranked sixth with one loss, and now plays a very important game in Ann Arbor on Saturday.
Last 5 Games
IU
Result
ATS
Total
vs MIA
W21 - 27
W0
46
vs ORE
W22 - 56
W-3.5
71
vs ALA
W3 - 38
W-7.0
38
@ OSU
W13 - 10
W+2.5
47
@ PUR
W56 - 3
W-52.5
54
MICH
Result
ATS
Total
@ TEX
L27 - 41
L+3.5
59
vs OSU
L27 - 9
L+13.5
46
@ MD
W45 - 20
W-21.5
58
@ NU
W24 - 22
L-6.5
42
vs PUR
W16 - 21
L-5.5
-
Indiana lost a lot of really good players off their championship team a year ago. The biggest loss was going to be replacing #1 overall pick and Heisman trophy winner, Fernando Mendoza. Josh Hoover needs to play a lot better than he did vs Ohio State for Indiana to win on the road on Saturday. Too many times he was inaccurate against the Buckeyes. Going up against a very talented Michigan defense if he struggles again the Wolverines could pull the upset.
Michigan is dealing with QB problems of their own as well. Bryce Underwood, who Michigan gave 12 million dollars to in NIL money has been terrible. After a scoreless first half last week against Penn State, Head Coach Kyle Whittingham decided to make a change. He put in Tommy Carr at QB and the offense put up 21 second half points. I would expect to see Tommy Carr again at QB this week for the Maize and Blue.
Indiana Hoosiers vs Michigan Wolverines: NCAA Football Expert Picks
Freshman Tommy Carr looks to lead Michigan to the upset over Indiana
Matchup Information – Indiana vs Michigan– October 24
- Venue & Location: Michigan Stadium ( Ann Arbor, MI)
- Date: Saturday, October, 24, 2026
- Kick Off: Noon ET
- Broadcast: FOX
Indiana vs Michigan Betting Odds
Odds listed are from BetOnline as of Wednesday, October 21, 2026 at 10:20 a.m. eastern.
Spread
- Indiana -7 (-112)
- Michigan +7 (-108)
Moneyline
- Indiana -280
- Michigan +230
Total
- Over 41.5 (-110)
- Under 41.5 (-110)
Indiana vs Michigan Prediction: Indiana Wins, Michigan Covers, Under 41.5
Best Bet: Michigan +7 (-108) BetOnline
Indiana suffered their first loss on Saturday since 2024 when they played Notre Dame in South Bend in the College Football playoff. It's only the third time Cignetti has lost since he's arrived in Bloomington and still only the two teams to beat him are Notre Dame and Ohio State. It's really tough to beat Indiana, but they do play plenty of close games, especially difficult true road games.
Last year, Indiana went on the road and played at Iowa and at Penn State. They defeated the Hawkeyes, 20-15 and beat Penn State, 27-24. Two weeks ago they went on the road to Lincoln, Nebraska and beat the Huskers, 20-17. This week they take on Michigan who has a similar DNA to all of those same teams. Good defense, struggling offense, first to 20 points probably wins the game. In those kinds of games Indiana has won, but they've all been within a touchdown. I'm expecting a similar result on Saturday.
Plus, the spot is not ideal for Indiana. Alabama just dealt with this playing Georgia and Tennessee. The Crimson Tide had a really tough home loss to Georgia and then the following week went to Knoxville and lost outright as a touchdown favorite to Tennessee. After a brutal loss at home to Ohio State now Indiana has to go on the road as a touchdown favorite against Michigan.
This Michigan team has played everyone close this season. They are 4-2 on the year and five of their games have been decided by one score. This game for me is all about the number. Getting a +7 or higher is a bet for me on Michigan. I think Indiana wins the game, but it's going to be close. Michigan's defense will keep them in the game and Tommy Carr at QB should give them more consistent offense then Bryce Underwood has.
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