Friday Night Lights: NCAA Football Expert Picks & Predictions (9/25)
Written by: Nate Hornung
Last Update: Fri Sep 25, 2026, 10:14 am ET
Read Time: 5 minutes
ncaaf
Spread
Total
Moneyline
-6.5
-110
51
-110o
-250
Spread
Total
Moneyline
+6.5
-105
50
-105u
+215
Friday is usually reserved for high school football, especially in Texas. However there are five games on tonight's NCAA Football slate as well. Our analysts dug into the betting board and found a couple of their favorite picks that are worth wagering on this weekend. Read below to get their thoughts, and see if they align with your game script as well. Will you be tailing or fading our experts tonight?
Check out the best odds on the market and tons of picks for the NCAA Football Season.
NCAA Football Friday's Predictions – September 25
Navy Midshipmen vs. UAB Blazers NCAA Football Picks
Braxton Woodson leads the Midshipmen with 296 rushing yards this year and four touchdowns
Best Bet: Navy -6.5 (-110) BetOnline
The Navy Midshipmen find themselves on the road tonight against the UAB Blazers. In this American Conference showdown, the visitors are favored by just under a touchdown at home, and I'm more than willing to back them to get the job done. Ultimately, Navy is just the much stronger team here. They are coming off a bye week following a road loss to Florida Atlantic and they have an extra day of rest before taking on Air Force next week. After a loss in their conference opener, I expect them to have plenty of motivation to turn things around.
We all know Navy runs the ball, over 60% of the time to be exact, but they do so for nearly seven yards per carry, ranking second in the nation. They will pound the ground tonight, and they should have tons of success doing so. UAB's rushing defense is bottom 25 in the country in terms of rushing yards allowed per game. They gave up 150 to Illinois, over 200 to UL Monroe, and 225 to Louisiana. Navy is a better running team than any of those listed.
Look for the Midshipmen to do whatever they please on offense, chewing up plenty of clock and keeping the Blazer's offense on the sidelines. Plus I believe Navy's defensive unit can slow down UAB enough to cover this touchdown spread with ease.
Northwestern Wildcats vs. #5 Indiana Hoosiers NCAA Football Picks
Turbo Richard leads the Hoosiers with over 300 rushing yards so far this season and four touchdowns
Best Bet: Turbo Richard 70+ Rushing Yards/Anytime TD (-105) BetOnline
Turbo Richard has stepped in as the Hoosiers lead back this season, and he's lived up to the hype. He's scored in all three games (four total), and has gone for 58, 108, and 149 rushing yards so far. Tonight we are bringing his yardage prop down from about 92 to just 70, and adding him to find the end zone again. I am not worried about the Hoosiers playing down to the level of the Wildcats. Curt Cignetti will have his guys ready to go on Friday night, as a game at Rutgers next Saturday shouldn't be a look ahead spot.
Richard has actually been getting less carries than Lee Beebe Jr., but he's certainly been more efficient with the football, and I don't think we will need more than 15 touches to get over the hump here, as Northwestern's rushing defense isn't anything to worry about.
The Wildcats allowed 147 rushing yards to South Dakota State, coming out to 3.7 per carry for the team, with the lead RB going for 79 yards and a score on 19 carries. Against Colorado, they gave up 180 total yards on the ground, good for 5.5 per carry, with the lead back running just eight times for 91 yards.
For this price of nearly even money, I'll take Richard to have himself a night at home. Feel free to bump this up to 80+ yards to get +120 as I couldn't find a 75+ line to meet in the middle around +110.
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Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.
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